Viral Vector Production

Celledonia™’s predictive, label-free AuraCyt™ technology brings a new level of confidence to lentiviral and AAV manufacturing. By analysing intrinsic cell properties rapidly, AuraCyt™ provides immediate insight into vector-producing cells, predicting health, productivity, and product quality.

AuraCyt™ enables teams to:

    • Choose host lines with lower impurity levels (e.g., HEK host lines with reduced exosome output) to maintain product purity and consistency.
    • Predict high-performing transfection events early, identifying which will produce optimal viral vector titres (lentivirus or AAV).
    • Improve workflow efficiency by forecasting performance and reducing analytical burden.
    • Monitor manufacturing events to distinguish productive vs. non-productive transfection events directly from cell-based measurements.
    • Track key process steps to enable fail-fast decisions and strengthen overall process robustness.
    • Support stable producer-line development by predicting clones sustaining productivity and quality across multiple passages.

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